Вие сте в: Начало // Всички публикации, За медицински специалисти // UCB ??N�?�??N?N�?�???? ?????? ????N�???�??N�??N� ???� N�N?????N�-???�??N�??N�???�??N�?�N�??N? N�?�??N�??N� ?�?�N�?� (TNFI�) ?�?� ?�?�N�?�?????� ???� N�?�?????�N�???????�?? ?�N�N�N�??N�

UCB ??N�?�??N?N�?�???? ?????? ????N�???�??N�??N� ???� N�N?????N�-???�??N�??N�???�??N�?�N�??N? N�?�??N�??N� ?�?�N�?� (TNFI�) ?�?� ?�?�N�?�?????� ???� N�?�?????�N�???????�?? ?�N�N�N�??N�

UCB, ???????�N�?� ?�????N�?�N�???�N�?�??N�??N�???� ?????????�????N?, ??N�?�??N?N�?�???? ?? ?�NS?�???�N�??N? certolizumab pegol – ?????? ????N�???�??N�??N� ???� N�N?????N�-???�??N�??N�???�??N�?�N�??N? N�?�??N�??N� ?�?�N�?� (TNFI�) ?�?� ?�?�N�?�?????� ???� N�?�?????�N�???????�?? ?�N�N�N�??N�. ??NS?�??N�???�N�?? ?�?� ??N?NSN�?�N?N�???�???? ???? ??N�?�???� ???� N??????????�??N???, ??N�???�?????�??N�?�?? N?NS?????�N?N�???? N? ?�NS?�???�N�N?????N�?? ??N�N??�?�N?N�???? ???? N�?�?????�N�???�??????N?, ??N�?????�???�?? ???� 11 NZ???? N�.??. ?? N�??N�?�?� ?? ?Y?�??????????.

?�-N� ???�?�?�???� ?�???????�???????�, N???N�?�????N�?�?� ???� UCB a�� ?�NS?�???�N�??N?, ????N�??N�????N�?� ?�?� ???�N?N�???????�N??�?�???????�N�?�?�N????�N�?� ?? N�?�?�?????????� ???�??????N?N� ???� ?????????�????N?N�?�. UCB e ???????�N�?� N????�N�???????� ?�????N�?�N�???�N�?�??N�??N�???� ?????????�????N?, ??N????????�???� ???� N????????�?�???� ???????�?????�N�??N? ??N� N�N�?�????N�????, ?????????�N�???? ?? ???????�?�?�?? ??????N�. a�??????????? ?????????�?????? N�??NSN�??N?N�, N�?� N�N?N�???�N�?� ???????�?�N�?� N????�?� N??� ???�N�???�??N�??N�?�, ???? ?�?� UCB N�?????� ?� ???�??N?N�????N�?�?�????N?N�. ?�N?NSN�????N?N� ?????� ???� ???�?�???�???� ???� N�??N�?�N�?� N? N�?�?�???? ?�?�?�???�N????�????N? ???�N�?? ???� a�????�N�???�??N�??a�?, ?� ???�N�?? ???� ??????????????N??�?�???? ?�??N�????N?N�?? N? ?�??????N� ???�??NS?? N�N?N�????N�?? ?�?�?�???�N????�???�. ?????� N????� ????N�???? N? N�?????�, ?????�N�?? ??N�?�?????? a�� ???� ??N�?�????N?N�?�??N????� ?�N�?????�N????? ?�?�???�N�N?N�???� ???� N�??N�?�N�?� N? N�N�??????N�???? ?? N�?�?�???? ?�?�?�???�N????�????N?a�?, ??????N�?�N�N�?� ??-N� ?�???????�???????�.

UCB ?� ??N�???�???�???� ???� N�?�?�N�?�?�??N�???�???�N�?? ???� ?????????�N�???????? ?�?�N�?�????N? ?? ???�?�?�N?N�N�?� ???� ????N??????�??????N�????N�?� ???�N�N?N??�????N? ?? N? certolizumab pegol ????N�??NSN�?�???�???� N?????N?N�?� ??N�????????N�????N?N� ?�?� ?????????�N�N????�???� ?�??????N�?� ???� ???�N�???�??N�??N�?� N? N�?�?????�N�???????�?? ?�N�N�N�??N�.

UCB N??� ?�?????�?�??N�?� ?? ??N�?�????N?N�?�??N????�N�?? ???� N�?�N??�????N?, ??????N�?? ???�??N�??NSN�?�N?N� ?�?�N�?�?????�N�?? N�N�?�?� N?N????�N????? ???�N�N�??N???N�N?N�???? N?NSN? ?�??N�?�??????N�?� N????�N�???�?�??N?N�??, N�N�?�?� ??N�????N�?�???? ?�?� ????????N�?�???� ???� ???�N�???�??N�??N�?� ?? ?????????�N�???????� ???�N?N�???????�N??�?�???????�N�?�?�N????� ?? N�?�?�?????????� N?N�N�?�N�?�????N?.

?�?�?????�N�??????????N?N� ?�N�N�N�??N� ?� N�N�??????N�???? ??NS?�???�?�??N�?�?�???? N?N�?�?????? ?�?�?�???�N????�???�, ???????�N�?? ???? ???????�?�???????�??N�?�???�. ?�?�?�???�N????�???�N�?? ???????? ???? ????N�?�????N�?�???� ???????????�????N?N� ?? N�N�?�?????? N???N�?�?�???�???� ?? ????N�?�?�?�?????� ???� N?N�?�????N�?� ?? ????N?N�??N�?�, ?????�N�?? ???�N�N?N??�???� ???�N�?�N?N�????N�?? ???� ?�??????N� ???� ???�N�???�??N�??N�?�. ?z??N�?�????N�?�?????�N�?? ???� N�???�??N�?�N????�N�?� N�N?????N�??N? ?? ???????????�????N?N�N�?�, ????????N??�???�N�?� ?�???�???� ?? N?????N�?� ??N�?? ???�N�???�??N�??N�?� N? N�?�?????�N�???????�?? ?�N�N�N�??N� ?�?�N?N????�N� ??NS?�?????�????N?N�N�?� ???? ???� N??� N???N�?�??N?N� ???�??N�?? N? ???????�N????�N�?� N�?�?�??N�?�, N�?�???� ?? ???� ???�??NS?�??N????�N� ?�?�??NS?�?�?�????N?N�?� N??? ???� N�?�?�??N�????N�?? ??N?N?N�?? ?? ?�?�N�N�N?????N????�N� N?????N????�????N?N�N�?� ???? ???� N?N�?�N?N�???�N� ?? N??�???�?????? ?? N???N�???�?�???? ?�??N�????????N?N�??. ?�?�?????�N�??????????N?N� ?�N�N�N�??N� ?� N???N�???�?�?????�???�N�?????? ?�?�?�???�N????�???� N?NSN? ?�???�N�??N�?�?�???? ???�????N�????N????? ?? ??????????????N�?�N????? ???�??N??????� ??NSN�N�N? ???�N�?�N?N�????N�??.

???� N??????????�??N????� ?�N?N�?� ??N�?�??N?N�?�???�???? ??N�?�????N�NS????N�?� ???� EULAR ?�?� ?�?�N�?�?????� ???� N�?�?????�N�??????????N? ?�N�N�N�??N� N?NSN? N?????N�?�N�??N�???? ?? ?�?????�??????N�???? ?�???�?�N?N�-????????N�??N�??N�?�N�?? ?�??N�??N�?�?????�N�??N�???? N?N�?�??N?N�???� (DMARDs) ?? ???�NZ????????N�N�????????????. ??????N�?�?? ??N�?�????N�NS????N�?� N�?�?� ???� ?�?�N�?�?????�N�?? N�N�N??�???� ???� ?�NS???� ????N?N�?????�???� ???� N�?�????N???N? ???�?? ????N????� ?�??N�????????N?N� ???� ?�?�?�???�N????�???�N�??, ?????�????N�?? ?� ??NS?�?????�???? ????-N�?�???? ??N�?? ??N??�???? ???�N�???�??N�, ?? ???????�N�?? N�?�?�N�?� ???� ?�NS???� ????N?N�???????�N�?�, N??� ??N�?�????N�NSN�???� ????N�??????N�?�???� ???� ?�?�N�?�?????�N�?? ???� ??N??�???? 1-3 ???�N??�N�?� ?? N?N�N�????N�???? ????????N�??N�??N�?�???�.1

?�?�?????�N�???�???�??N�?� ?????�N�?� ??NS?�?????�????N?N�N�?� ???� N??� ?�?�?????�???�N?N� N? ???�N?N�????N�?� ???�?????? ?? ???� ?�?�???�???�N� N???????N�?� ??NS??N�??N??? ??NS?? ?�??N????�N�N�?? ?? ???�?�?�N?N�N�?� ???� N�?�?????�N�??????????N? ?�N�N�N�??N� a�� ??N�??N�. ?�?�N??? ?�?�N???????, ??N�??N�. ?�?�?�N�??????N� ?s???�?�N�????, ????N�. ?�?�???�N�?� ?Y?�??N�?�???� ?? ????N�. ?�N????�?? ??N�?????�????.

Certolizumab pegol ?� N�?�???????�?????�??N�?�??, N�N????�?????�??N�?�?? Fab’ ?�??N�??N�N??�?? N�N�?�?????�??N� N?N�?�N�N? N�N?????N� – ???�??N�??N�???�??N�?�N�??N? N�?�??N�??N� ?�?�N�?� (TNFI�), ?�??N???N�?�N???N�?�?? ?? Escherichia coli ?? ??????NZ????N�?�?? N? ?????�???�N�???�?�?????�???????� (PEG). Certolizumab pegol ?????� ????N????? ?�N�??????N�?�N� ??NS?? N�?????�N?????N? TNFI� ?? N??�?�?�??N�???????? ???�N?N�N�?�?�???�??N�?� TNFI�.2

Certolizumab pegol e ?�??????N?N�???�????N?N� ???�?????�??N�?�?? TNFI� ????N�???�??N�??N�.A� ?Y?�?????�??N�?�???�N�?? a?� ???????�?�?�??N�????N�?? N???NSN�?�???�???� ???� PEG ?????�?????�N�??N�?� ??NS?? ???�??N�??????N�?� a?� ?�?�?�?�??N? ?�?�??????????N�?�???�N�?? ???� N�?�?�?? ?�????????N�?? ??N� N�??N�??N??�?�N�??N?N�?� N? ????????N�N�?� ???� ???????�?�N?N�???? ???�N�?�?????�????, ?????�NZN�??N�?�?�???? ?????????�?�?? ?�NS?�N�?�N�?�?? ???�??N�NS??N?, ?????????�?�???� ??N�??N�?�???�???�?� ?? ?????????�?�???� ????N????????�??????N?N�.2

Certolizumab pegol ???� N?NS??NSN�?�?� N�N�?�?????�??N�???? ??N�??N?N�?�?�???�?�N�???????�?? (Fc) N?N�?�N?N�NS??, ??????N�?? ????N�???�?�???? ??N�??N?NSN?N�???� ?? ??NS?�????N�?? ?�??N�??N�N??�??, ?? N�?�?�N??�N�?�N� ???� ?????�N�?? ???� N??� N???NSN�?�???� ?????????�?�???�??N�???? ?? ???� ???????? ???? ?�??N�??N�N??�???�?�????N??????� ???�?�N�NSN�???????�??????N�?�???� N�??N�??N�????N???N�????N?N� in vitro. ???� N??� ??N�?�?????�?????????� ?�??????N�???�?� in vitro ???� ???�?�N�??N�?� ??N� ???�N�??N�?�N�???� N�?????�N????� ??N�NS?? ????????N�??N�?? ???�?? ?�????N�??N�??N�??, ???�?? ???�??N�?�??N??�?�N�??N? ???� ???�N?N�N�??N�???�??N�?�.2

Certolizumab pegol ?? ???????�?????�N�??N? N? ???�N�??N�N�?�??N??�N� (MTX) e ???????�?�?�?? ?�?� ?�?�N�?�?????� ???� N????�N�?�?? ???? N�?�?�NS?? ?�??N�?????�?? N�?�?????�N�???????�?? ?�N�N�N�??N� (RA) ??N�?? ??NS?�N�?�N?N�????, ??N�?? ??????N�?? ??N�????????N�NSN� ??NS?? ?�???�?�N?N�-????????N�??N�??N�?�N�?? ?�??N�??N�?�?????�N�??N�???? ?�?�???�N�N?N�???�, ?????�NZN�??N�?�?�???? ???�N�??N�N�?�??N??�N�, ?� ???�????N?N�?�N�NSN�?�??. Certolizumab pegol ?????�?� ???� N??� ??N�???�?�???� ?? ???�N�?? ????????N�?�N�?�????N? ?? N??�N?N�?�?? ???� ???�????????N???????N?N� ??NS?? ???�N�??N�N�?�??N??�N� ???�?? ???????�N�?? ??N�????NS?�?�??N�?�?�????N�?? ?�?�N�?�?????� N? ???�N�??N�N�?�??N??�N� ?� ???�??????N�????N?N�??.2

?YN�?�????N�NSN�???�???�N�?� ???�N�?�?�???� ?????�?� certolizumab pegol ??N�?? ??NS?�N�?�N?N�???? N? N�?�?????�N�???????�?? ?�N�N�N�??N� ?� 400 mg (2 ?????�?�??N�??N�?�????N? ?????�??????, ??N?N????? ???? 200 mg) ???� N??�??????N�?� 0, 2 ?? 4, ????N??�?�?????�???� ??N� ????????NSN�?�?�N�?� ?????�?� ??N� 200 mg ???� ??N??�???? 2 N??�??????N�??. ?Y?? ??N�?�???� ???� ?�?�N�?�?????�N�?? N? certolizumab pegol ?????? N�N�N??�???� ???� ?�NS???� ??N�????NS?�?�?�?? ??N�?? ???�???�N�??????????N?N�.

???�?�??N�????N�?� ???�?????? ??N�?�???????�?�???�N�, N�?� ??N??????? ???�N�???�??N�?? ???????�?�???�N� ???�??????N�?�?? ??N�????????N� N??�?�?? 1 N??�??????N�?�, ?� ???????�N�?�N�?? – ???? 12-N??�??????N�???? ?�?�N�?�?????�. ???�???�N�?????????� ?� ?????????�N�?�?�???� ??N�?�N�?�?????� ?�?� ??N�????NS?�?�?�???�???�N�?? ???� ?�?�N�?�?????�N�?? ??N�?? ???�N�???�??N�??, ??????N�?? ???� N??� ???????�?�?�?�?? ???????�?�?�N�?�?�N?N�???? ?�?� N�?�N�?�???�??N�??N�???� ?????�?�?� ??N�?�?� ??NSN�????N�?� 12 N??�??????N�?? ?�?�N�?�?????�.2

????N�??N�???�N�??N? ??N�????N????? ?�?�?�?????�N?????N?N�N�?� ???� certolizumab pegol:

Certolizumab pegol ?� ???�N??�?�?????�?? ??N�?? 2367 ???�N�???�??N�?? N? N�?�?????�N�???????�?? ?�N�N�N�??N� ?? ??????N�N�???�??N�?�???? ?? ??N�????N�?�???? ??N�??N?N�???�????N? ?? ??N�????NS?�?�?�?????� ???? 57 ???�N??�N�?�. ?�?�N?N�?? ???�?�?�?�?�???? N�?�?�??N�???? (a�? 1/100 ???? < 1/10), N?NS???�N�?�???�???? ???? ??N�?�???� ???� ???�??????N�????N�?� ??N�??N?N�???�????N? N? certolizumab pegol ??N�?? N�?�?????�N�???????�?? ?�N�N�N�??N� ?? ????N?N�???�N�???�N�???????????�N�?� N?????N�N�?�?�?�, N??� ????N�N?N????? ????N�?�??N�???? (?????�NZN�??N�?�?�???? N�?�N�???�N?, ???�?????�?????�????N�N?N? ?? ????N�?�N??�??N�?�), ?�?�??N�?�N�???�?�???? ????N�?�??N�???? (?????�NZN�??N�?�?�???? ?�?�N?N�?�N?), ???�N�????, ???�?�?????�???�???� (?????�NZN�??N�?�?�???? ??????N�?�???�), N??�N�???????? ???�N�N?N??�????N?, ?�???�??????N�???�???? ???�N�N?N??�????N?, ?�?�?????????�????N? (?????�NZN�??N�?�?�???? ???�N?N�N�?????�????N?, ?�????N�?????�????N?), N�?????�N�N�??????N?, N�?�???�N�??N� (?????�NZN�??N�?�?�???? ????????N??�?????� ???� N�?�N�??????N�???�????N�?� ?�???�??????), ????N�?�??N???N?, ?�???�???� (??N�?????�?????�???? ??N?N?N�??), N?????N�?�, ??N�N?N�??N�N?N? (??N�?????�?????�???? ??N?N?N�??), N�?�?�??N�??N? ???� ??N?N?N�??N�?? ???� ??N�???�???�?�?????�.???�?�???? ???�?�?�?�?�???? N�?�?�??N�???? ?????�NZN�???�N� N??�??N???N?, ??????N�N�NZ????N?N�??N�???? ????N�?�??N�????, N�N??�?�N�??N??�???�?�, N�?�N�???�N? ?�??N?N�?�N�, ?�????N�????, ?�?�?????�????N?, N�N?????N�?? ???� ???�NSN�????N�?� ??N�???�????, ?�???????????�??N�??N�??N�?�?? ??N�????, ???�N�???????????????�N�???? (?????�NZN�??N�?�?�???? N?NSN�???�N�???� ???�????N?N�?�N�NSN�????N?N�), ??N?N�?�????N�???? ???�N�N?N??�????N? ???� ????N�?????�N�???�N�?� ?�N�N�?�N�??N?, ???�??N�??N�?????�????N?, N�?????�N�?????�??N??�?�N�??N? (?????�NZN�??N�?�?�???? N�N�?????�??N�?�?�?�??N�, ?�?�?�????N�???�?�?? ?�???�???�???�NS??), ?????�NSN�????N?NS?????? ????N�?????�??N�, ???�N???N??�??N�??, N�?�???�N�??N�, N�?�???�N�?????�N�??N? (?????�NZN�??N�?�?�???? N�??N�???�?�), ?�NS?�N�?�N�???? N???N�?�?�???�???�, ???�N�N�?????�N�??N? (?????�NZN�??N�?�?�???? ???�N�N�??N�). ?YN�??N�?�??N�NSN� ???� ???�N�???�??N�??N�?�, ??N�?�??NSN????�?�?? ?�?�N�?�?????�N�?? ????N�?�???? ???�?�?�?�?�???? N?NS?�??N�??N? ???? ??N�?�???� ???�A� ??????N�N�???�??N�?�????N�?� ??N�??N?N�???�????N?, ?� 5% ??N�?? ???�N�???�??N�??N�?� ???� ?�?�N�?�?????� N? certolizumab pegol ?? 2,5% ??N�?? ???�N�???�??N�??N�?�, ??N�???�???�?�?? ???�?�N�?�?�??. 2

Certolizumab pegol ?� ??N�??N�?????????????�?�?�?? ??N�?? ???�N�???�??N�?? N?NSN? N???N�NSN�N�N???N?N�????N�?�?�????N?N� ??NS?? ?�??N�????????N�?? ???�N�?�N?N�???? ???�?? ??N??????� ??N� ????????N�????N�?� ???�N�?�N?N�???�, ?�??N�???????� N�N??�?�N�??N??�???�?� ???�?? ??N�N????? N�?�?�???? ????N�?�??N�????, ???�N�?? N??�??N???N? ???�?? ??????N�N�NZ????N?N�??N�???? ????N�?�??N�????, N????�N�?�???� ???? N�?�?�???� N?NSN�???�N�???� ???�????N?N�?�N�NSN�????N?N� (???�?�N? ???? NYHA – III/IV). 2

?YN�?�???? ?�?�????N�???�???� ???� ?�?�N�?�?????�N�?? N? certolizumab pegol ??N???N�???? ???�N�???�??N�?? N�N�N??�???� ???� ?�NS???�N� ??N�?�???�?�???�???? ?�?� ???�?�??N�???�N�?? ???�??N�?? ???� ?�??N�???????�, N�?�???� ?? ???� ???�?�??N�???????� (?�?�N�?�??N�???�) N�N??�?�N�??N??�???�???� ????N�?�??N�??N?. ?YN�?? ?????�??????N?N�??N�??N�?�???� ???� ?�??N�???????� N�N??�?�N�??N??�???�?� ??N�?�???? ???�?? ???? ??N�?�???� ???� ?�?�N�?�?????�N�?? ???� N�N�N??�???� ???� N??� ?�?�????N�???� ?�?�N�?�?????� N? certolizumab pegol ???�?? N�?? N�N�N??�???� ???� ?�NS???� ??N�?�N?N?N�?�???????�????. 2

TNF ?�?�?????�N�??, ?????�NZN�??N�?�?�???? certolizumab pegol, ???????�N� ???� N????�?�??N�?�N� N�??N????� ??N�: N�?�?�??N�?????�N�??N? ???� N�?�???�N�??N� ?� ????N�N?N? (HBV) ??N�?? ???�N�???�??N�??, ??????N�?? N??� N�N�??????N�???? ????N???N�?�?�?? ???� N�???�?? ????N�N?N?; ????N????� ???�?? ???�??N?N�N�N????� ???� ???�??????N�????N�?� N???????N�?????? ??/???�?? N�?�??N�???�??????N�?�N�N????? ???�?????? ?�?� ???�?????�?�???????�??N�?�N�?? ?�?�?�???�N????�???�; ?�??N�????N????�?�?�N�???? ?�??N�??N�?�?�?� (ANA) ?? ?? N�?�?????? N??�N?N�?�?? ???? ????N????�N�?� ???� ?�N???N?N?-?????????�?�?? N???????N�????; N�?�?�??N�???? ???� N�?�?�???� N???N�NSN�N�N???N?N�????N�?�?�????N?N�. ?YN�?? ????N????�N�?� ???� N�?�?�???? N�?�?�??N�???? ??N�???�???�?�?????�N�?? ???� certolizumab pegol N�N�N??�???� ???� ?�NS???� ???�?�?�?�?�?????? ??N�?�N?N?N�?�???????�???? ?? ?�NS???� ???�?�???�N�?�???? ??????N�????N?N�?? ?�?�N�?�?????�. 2

??NS???�?�N????? N?NS??N�?�???�??????N�?� ?�???�????N? ???�N�??N?N�????N?N� N�??N??? ??N� N�?�?�????N�???�N�?? ???� ?�????N�????, ?�?�?????�????N? ???�?? ??N�N????? ?�?�?????�N�?�N?N�???�???? ?�?�?�???�N????�????N? ??N�?? ???�N�???�??N�??N�?� ???� ?�?�N�?�?????� N? TNF ?�??N�?�????????N?N� ???� ?????�?� ???� ?�NS???� ???�???�NZN�?�??. ?YN�?? ???�N�???�??N�??, ?�?�??N????�???? N? certolizumab pegol, N??� N?NS???�N�?�???�???? N�?�?????? N??�N?N�?�?? ???� ???�??N�???�??????N�???? ???�N�N?N??�????N?, ?????�NZN�??N�?�?�???? ??N�?????�??NSN�??, ???�??N�??N� ?? ???�N�??N�?�N�???� ???�??N�?????�N�??N?. 2

???�?�?�?�?�???? N�?�?�??N�???? ??N� N?N�N�?�???� ???� ??N�NS??N�?�, ?????�NZN�??N�?�?�???? ???�??????N�???? ?�???�N�?????� N�??N�?????�????N? (???�??N�. ?�?�?????????�????N?, ???�??N�??N�?????�????N?, N�N�?????�??N�??N�?????�????N?, N??� N?NS???�N�?�???�???? ??N�?? certolizumab pegol. ?�N???N�???? ???�N�???�??N�?? N�N�N??�???� ???� ?�NS???�N� ????N?NS???�N�???�???? ???� N�NSN�N?N?N� ???�?�?�?�?�?????� ?�?�???�N�N????� ????????N� ??N�?? ????N????�N�?� ???� ??N�???�???�N�?? ?? N???????N�??????, ??N�?�???????�?�???�N�?? ??N�NS?????� ????N???N�?�?�??N? ???�?? ????N�?�??N�??N? (???�??N�. ???�N�N???N?N�??N�?�N�?� N�N�?�N????�, ???�N�NSN�N�???�???�, ??NSN�???�???�, ?�?�?�??????N?N�) ???? ??N�?�???� ???� ?�?�N�?�?????�N�?? N? certolizumab pegol. ??N�N??�???� ???� ?�NS???� ???�????N??�?�???? ??N�?�N?N?N�?�??????N????�???� ???� ?�?�N�?�?????�N�?? N? certolizumab pegol ??N�?? ???�N�???�??N�?? N? ????N�??NSN�???�???? ?�???�N�?????? N�?�???�N�???�??????N�???? ???�N�N?N??�????N?. 2

???� N??� ??N�?�????N�NSN�???� ???????�??????N�?�???� ???� certolizumab pegol ?? ?�???�??????N�?� ???�?? ?�?�?�N�?�N�?�??N� ????N�?�???? ????N�?�??N�???�?�?�?? N????�?�??N�?�?? N�??N??? ??N� N�?�?�???? ????N�?�??N�????. ??N????� ???�?????? ??N�????N????? ??N�????????N�?� N???N�N????? ???�??N??????�N�???? ???�?? ??N�??N�??N�???? ??N�?�???�???�???� ???� ????N�?�??N�??N? N? ????????N�N�?� ???� ?�?????? ???�??N??????? ??N�?? ???�N�???�??N�??, ??N�???�???�N�?? certolizumab pegol. ?�?????? ???�?? ?�N�?�??NZ??N�?�???? ???�??N??????? ???� N�N�N??�???� ???� ?�NS???�N� ??N�???�?�???�???? ?�????????N�?�???�?????? N? certolizumab pegol. ?Y?�N�???�??N�, ???�??N??????�N� N�??N�N?N�????N�???� ???�???�N??�, ???????�N�?? ??N�???�???� certolizumab pegol, N�N�N??�???� ?????????�N�?�?�???? ???� N??� ???�N??�?�?????� ?�?� ????N�?�??N�???? ?? ???� N??� ??N�?�????N�???�???�N� N?NS??N�???�N�????N�?� ???�N�????. 2 crestor walgreens price, crestor walgreens price, crestor walgreens price, crestor walgreens price, crestor walgreens price, crestor walgreens price.

?????�N? ?�?�?????�???�??N�?� N??� N? ??NS?�???�N�?� ????N�??N�???�N�??N? ?�?� ??N�????N???N�?� ???? ??N�????N??�?????� ???� ??N�N?????N�?� ???�?�?�?�?�???? ?�N�?�??N�??, ??NS?�????N? ??N�??N�???� ???� ?�?�?�?????�N?????N?N� ?? ??N?N�?�???�?�?�N�?� ????N�??N�???�N�??N? ?�?� ??N�?�??????N????�???�.

Certolizumab pegol 200 mg ?????�?�??N�???????�?? N�?�?�N�????N� N??� ?????�???????� ?? ??N�?�?????�N�??N�?�?�???? ???�??NS?�???�???� N???N�????N�???????�. ?zN�??N?N????� N??� ???? ?�?�???�N�N????? ??N�?�??????N??�?????�. ?????�N? ??N�??N�?�N�?�N�?� ??N�?�N�???�N�?� N�?�N�?�??N�?�N�??N?N�?????� ???� ??N�????N???N�?�, ??N�?�???? ???� ??N�?�??????N??�N�?� certolizumab pegol. ?�?�N�?� ???� ????N??�?�?????? ???????�N�?�???� ?s???Y: 09.02.2011.

Certolizumab pegol ??N??� ??N�?� ???� N??� ??N�?�???�?�???� ?? ?�NS?�???�N�??N?.

?�?�N�?�N�?�??N�????:

1. Smolen J et al., Ann Rheum Dis 2010 69;964a��975.

2. Certolizumab pegol ?s???Y: 09.02.2011

Отговори

Copyright © 2009 ФОРУМ МЕДИКУС. All rights reserved.
   
Designed by My. Modified by ForumMedicus. Powered by WordPress.